We aim at elucidating, using bioinformatic methods, how interruptions in cellular regulatory mechanisms contribute to the development of human pathological conditions, primarily cancer.
Gene regulation is a multi-layered process and we mainly study three key tiers of it:
Regulation of gene transcription
Regulation of transcript stability
Regulation of protein translation
Dr. Rani Elkon
Our study of these tiers of gene regulation utilizes various cutting-edge deep-sequencing techniques that allow genomic-scale delineation of regulatory layers that were so far largely unexplored.